Endocrine Abstracts

Background: Primary hyperparathyroidism (PHPTH) refers to overproduction of PTH (parathyroid hormone) which leads to hypercalcaemia and hypophosphataemia. Preoperative imaging aims identification of a solitary parathyroid adenoma (PTA) or multiple gland hyperplasia. However, it is not always possible to identify the lesions, and in some situations imaging findings could be misleading.Case report: A 48-year old male, with personal history of differentiate...

Carcinoma of the thyroid gland is an uncommon cancer but is the most common malignancy of the endocrine system. The treatment of the thyroid cancer includes surgery, radioactive iodine and hormone treatment. Postoperative hypothyroidism is the most common complication of thyroidectomy for thyroid cancer. After thyroidectomy, the patient takes a thyroid hormone drug (levothyroxine) in supresive dose for the rest of his life.In hypothyroidism there has bee...

Background: Growth hormone directly stimulates tumour growth, angiogenesis and metastasis through autocrine and paracrine effects on cancer cells, while through IGF1 inhibits apoptosis and promotes epithelial proliferation. Although disputed, some studies have shown an increased cancer incidence in acromegaly patients, especially in uncontrolled subjects, while others have not.Aim: To assess prevalence of cancer in a cohort of patients with long term tre...

Background: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. Standard treatment includes thyroidectomy (extention depending on tumour size, pathology and lymph nodes involvement). If indicated, radioiodine therapy after TSH stimulation either by levothyroxine withdrawal or rhTSH administration is recommended. In patients with thyrotropin deficiency rhTSH administration is mandatory.Case report: A 30-year-old woman, resident in...

Often discovered incidentally, small foci (≤2 cm) of papillary thyroid carcinomas (PTC) are its most frequent presentation. Despite favourable prognosis, the extent of surgery and use of radioablation is still controversial.Objective: Prospective cohort study of all patients admitted between 2007 and 2011, for thyroid surgery in the Institute of Endocrinology, Bucharest, Romania, and had pT1a or pT1b PTC.Patients and methods:...

Introduction: Autoimmune thyroiditis is a disease where the immune system attacks and destroys the thyroid gland. If the pathological exam lacks, the serum antithyroid antibodies are used to diagnose it. Also a useful tool is represented by the anterior cervical ultrasound.Aim: Our aim was to study the ultrasound phenotype in patients diagnosed with Hashimoto’s thyroiditis (HT+).Material and methods: The patients were investig...

Introduction: Galactocele is a rare form of cystic, benign lesion of the breast, occurring when a mammary duct becomes obstructed and over filled with milk. It usually appears in postpartum women, either lactating or not, but it is extremely rarely seen in postmenopausal women or in men.Subject: We present the case of a 37-year-old female patient, nullipara, diagnosed with a microprolactinoma 18 months ago, and treated with bromocriptine since then (7.5 ...

Background: Differentiated thyroid cancer (DTC) encompases a wide spectrum of disease from clinically insignificant micro-tumors to aggressive cancers. The molecular signature can be used to predict tumor behaviour, and the co-existence of BRAF and TERT promoter mutations has been identified as a marker of adverse prognosis, but we have yet no available molecular data for the Romanian population.Objectives: To determine the prevalence of BRAF V600E and T...

Background: Prevalence and type of amiodarone-induced thyroid dysfunction in a population depend on geographical iodine intake.Aims: To assess differences in amiodarone-induced thyrotoxicosis pattern before and after iodine supplementation.Patients and methods: 84 patients (41M/43F) with amiodarone-induced thyrotoxicosis, aged 60.1±11.9 years, were retrospectively reviewed. 28 patients were resident in former iodine-deficient ...

Introduction: Ectopic thyroid tissue (ETT) is a rare entity; it is more frequent in women (80%) and is usually located along the obliterated thyroglossal duct. ETT in the midline is even rarer (1.79%). Incidence of malignancy in this group is lower than in orthotopic thyroid nodules.Case report: A 40 years old woman, resident in iodine sufficient area, but originating from an iodine deficient area, presented for a midline neck mass. TSH and FT4 were meas...